Disputas: Haakon Karlsen

Haakon Karlsen disputerer 9. februar for doktorgraden med temaet "Smartphone-based urinary biomarker detection: an application-oriented device and algorithm."


09 Feb

Praktisk informasjon

  • Dato: 9. februar 2018
  • Tid: kl. 10.15 - 16.00
  • Sted: Campus Vestfold
  •  

    Til å bedømme avhandlingen er oppnevnt:

    • Professor José Higino Correia, University of Minho, Portugal

    • Professor Trond Storebakken, Fakultet for biovitenskap, NMBU,  Ås

    • Professor Per Øhlckers, Institutt for mikrosystemer, HSN


    Leder av disputas

    Instituttleder Yngvar Berg

    Veiledere

    • Professor Tao Dong, Institutt for mikrosystemer, HSN

    • Senior-forsker  Zhenhe Suo, Oslo Universitetssykehus, Oslo


    Program:

    Kl 10.15 Prøveforelesning: "Pre-screening and monitoring in water distribution networks  for water quality management"

    Kl 13.00 Disputas

    Prøveforelesning og disputas er åpen for alle interesserte.

    Det vil bli en sammenkomst umiddelbart etter disputasen.

Graden avlegges ved  Høgskolen i Sørøst-Norge (HSN), Fakultet for teknologi, naturvitenskap og maritime fag.

Om avhandlingen

This work focused on developing a diaper assay compatible with commercially available diapers for automatic collection of urine and screening of urinary biomarkers, accompanied by a smartphone application for analysis of results.

The diaper assay absorbs urine, and isolates it from the environment. Reaction pads with colorimetric chemicals change color depending on the biomarker levels in the urine and preserves result for up to 8 hours.
Haakon Karlsen - foto
The smartphone application functionality: 1) A photograph of the reaction colors, 2) detect alignment marks, 3) data extraction and 4) illumination and device independent classification of reaction colors according to a set of color references.

Persons of advanced age have higher risks of developing urinary tract infections than the general population, and increasingly so with declining levels of independence. Elderly patients in home care services are often incontinent and use adult diapers. The lack of control from incontinence combined with potentially declining cognitive abilities and strained human resources (number of visits and time per patient in the home care services) can make standard midstream clean-catch urine sampling slow and difficult. Urine samples can be collected with urinary catheters, but catheterization increases the risk of infection in addition to being uncomfortable. Empirical treatment with antibiotics without urine tests can lead to overuse of antibiotics.

The diaper assay and smartphone app gives home care nurses the opportunity to pre-screen urine tests to rule out negative samples, which do not require further analysis and instead focus on the samples that are likely positive. This pre-screening procedure has a potential to obtain results quicker, save time for the nurses, and prevent unnecessary catheterization, antibiotic treatment and laboratory analysis